Injectable Hydrogel Filaments For Biomedical Uses
AssigneeMicroVention, Inc.
InventorsMichael J. Constant, Gregory M. Cruise, E. Michael Keeley, Alejandro Berenstein
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Abstract
Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations with radiopaque hydrogel filaments with delayed controlled rates of expansion permitting the repositioning of the device once inside the structure or malformation. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.
Claims41
A device for implantation comprising:
- a difunctional, low molecular weight ethylenically unsaturated shapeable macromer;
- an ethylenically unsaturated monomer;
- and
- a visualization agent,
- wherein said device contains no support members and has a bending resistance between about 0.5 mg and 0.1 mg.
A method for preparing device for implantation in an animal comprising:
- a) combining a difunctional, low molecular weight ethylenically unsaturated shapeable macromer, an ethylenically unsaturated monomer, a visualization agent, and a solvent to prepare a prepolymer solution;
- and
- b) treating said prepolymer solution to prepare a hydrogel filament that is expansible at physiological conditions and has a bending resistance between about 0.5 mg and 0.1 mg.
A device for implantation in an animal comprising:
- a difunctional, low molecular weight ethylenically unsaturated shapeable macromer with a molecular weight of about 100 grams/mole to about 5000 grams/mole;
- an ethylenically unsaturated monomer;
- and
- a visualization agent,
- wherein said device contains no metallic support members and has a bending resistance between about 0.5 mg and 0.1 mg.
Dependencies are inferred from the claim text.