Administration of an adsorbent polymer for treatment of systemic inflammation
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsJohn A. Kellum, Mitchell P. Fink
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Abstract
The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.
Claims36
A method of ameliorating systemic inflammation in a patient suffering from or at risk of inflammation comprising:
- administering to the patient a therapeutically effective dose of a composition comprising polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer,
- wherein the administration results in enteral adsorption of an inflammatory mediator.
A method of treating a patient suffering from an inflammatory response comprising:
- administering to the patient a therapeutically effective dose of a composition consisting essentially of polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer.
A method of reducing systemic inflammation in a patient suffering from or at risk of same, comprising:
- orally administering to the patient a therapeutically effective dose of a composition comprising beads of a sorbent polymer that adsorbs a mediator of inflammation.
A method of ameliorating systemic inflammation in a patient comprising:
- initiating or exacerbating an inflammatory response in the patient;
- and
- administering to the patient a therapeutically effective dose of a composition comprising polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer.
Dependencies are inferred from the claim text.