Carnitine conjugates of adamantanamines derivatives as dual prodrugs for various uses

A compound, including its pharmaceutically-acceptable salts, of Formula (I) below,

• wherein:
• Z is a trialicyclic adamantane as shown by Formulae (A),
• wherein:
• R, R1, and R2 are each independently H or CH3:
• C1-C6 straight chain or branched alkyls, C3-C6 cycloalkyl, C2-C6 alkenyl, C2 C6 alkynyl;
• C6-C10 aryl unsubstituted or substituted with straight chain or branched C1-C6 alkyl, C1-C6 alkoxyl, 1,3-dioxolanyl, cyano, halo, nitro, trihaloalkyl, C1-C6 acyl, C1-C6 dialkylamino, C1-C6 acylamino, C1-C6 mercaptoalkyl;
• alkylaryl (C6-C10), such as a benzyl group unsubstituted or substituted with straight chain or branched C1-C6 alkyl, C1-C6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, acyl, C1-C6 dialkylamino, and C1-C6 mercaptoalkyl;
• and alkyldiaryls such as diphenylmethyl in which the aryls may be bridged by —CH2—CH2— or O or S, where the alkyldiaryls may be unsubstituted or substituted with straight chain or branched C1-C6 alkyl, C1-C6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C1-C6 acyl, C1-C6 dialkylamino, and C1-C6 mercaptoalkyl;
• n=0 or an integer from 1 through 6;
• Ŕ is H or C1-C4 straight-chain alkyl;
• Y is a moiety of Formulae, (D), and shown below,
• wherein,
• R1 is independently selected from the group consisting of straight or branched chain C1-C6 alkyl, C3-C6 cycloalkyl;
• C2-c6 alkenyl;
• C2-C6 alkynyl;
• C6-C10 aryl such as phenyl, naphthyl, and the like, or a heteroaryl such as furanyl, imidazolyl, pyrollyl, triazolyl, pyridyl, and the like, unsubstituted or substituted with one or more straight chain or branched C1-C6 alkyl, C1-C6 alkoxyl, 1,3-dioxolanyl, cyano, halo, nitro, trihaloalkyl, C1-C6 acyl, C1-C6 dialkylamino, C1-C6 acylamino, C1-C6 mercaptoalkyl;
• and straight or branched chain alkylaryl (C6-C10), such as a benzyl group, or an alkyl heteroaryl wherein the aryl or the hetroaryl group may be unsubstituted or substituted with one or more straight chain or branched C1-C6 alkyl, C1-C6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C1-C6 acyl, C1-C6 dialkylamino, and C1-C6 mercaptoalkyl, and alkyldiaryls such as diphenylmethyl in which the aryls may be bridged by —CH2—CH2— or O or S, where the alkyldiaryls may be unsubstituted or substituted with straight chain or branched C1-C6 alkyl, C1-C6 alkoxyl, 1,3-dioxolanyl, cyano, halo, trihaloalkyl, C1-C6 acyl, C1-C6 dialkylamino, and C1-C6 mercaptoalkyl;
• and
• X− is a pharmaceutically-acceptable inorganic or organic counter ion.