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US 2011/0212159 A1Published application
Vaccines
AssigneeGlaxosmithkline Biologicals SA
InventorsWilliam Ripley Ballou, Joseph D. Cohen
Life of this patent
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Abstract
The invention relates to use of an antigen derived from the circumsporozoite protein (CS) protein of Plasmodium falciparum which is expressed at the pre-erythrocytic stage of malarial infection in combination with a pharmaceutically acceptable adjuvant, in the manufacture of a medicament for vaccinating infants against malaria.
Claims22
1-15. (canceled)
A method for inducing an immune response against Plasmodium falciparum in an infant comprising
- a) selecting an infant at risk of malaria disease or infection;
- and
- b) administering an immunogenic composition comprising
- i) a polypeptide comprising a Plasmodium falciparum circumsporozoite protein (CS) antigen or an immunogenic fragment thereof, and
- ii) a pharmaceutically acceptable adjuvant,
- wherein the CS antigen is expressed at the pre-erythrocytic stage of malarial infection.
3 more elements
A method for treating, preventing or reducing the incidence of clinical malaria in an infant comprising
- a) selecting an infant at risk of malaria disease or infection;
- and
- b) administering an immunogenic composition comprising
- i) a polypeptide comprising a Plasmodium falciparum circumsporozoite protein (CS) antigen or an immunogenic fragment thereof, and
- ii) a pharmaceutically acceptable adjuvant,
- wherein the CS antigen is expressed at the pre-erythrocytic stage of malarial infection.
3 more elements
Dependencies are inferred from the claim text.