Immunocompatible chorionic membrane products
OwnerSamson Tom, Alla Danilkovitch +4inventors
InventorsSamson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
Life of this patent
Estimating the term…
Abstract
Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Claims21
1-121. (canceled)
A placental product comprising a cryopreservation medium and a chorionic membrane, wherein:
- a. the chorionic membrane comprises viable therapeutic cells and is substantially free of trophoblasts, CD14+ macrophages, or both trophoblasts and CD14+ macrophage;
- and
- b. the cryopreservation medium comprises a cryopreserving amount of a cryopreservative;
- and
- c. optionally, the chorionic membrane is substantially free of vascularized tissue or vascularized tissue-derived immunogenic cells.
Dependencies are inferred from the claim text.