Flexible, Compressed Intravaginal Rings, Methods of Making and Using the Same, and Apparatus for Making the Same
AssigneeTeva Women's Health, Inc.
InventorsSalah U. AHMED, Tahseen A. Chowdhury, Yi Luo
Life of this patent
Estimating the term…
Abstract
The present invention is directed to flexible, compressed intravaginal rings comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, and an active agent, and methods of making and using the same, and apparatus for making the same.
Claims29
A flexible, compressed intravaginal ring comprising a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, a thickener, and an active agent, wherein the thickener is present in a concentration of about 2% to about 20% by weight of the flexible, compressed intravaginal ring, and wherein the polymethacrylate has a glass transition temperature of about 10° C. to about 50° C.
The flexible, compressed intravaginal ring of claim 5, wherein the polymethacrylate and the plasticizer are present in a ratio of about 2:1 7:1 by weight.
A method of providing an active agent to a subject, the method comprising vaginally administering a flexible, compressed intravaginal ring to the subject, wherein the flexible, compressed intravaginal ring comprises a substantially homogeneous compressed mixture comprising a polymethacrylate, a plasticizer, a thickener, and an active agent.
A process for preparing a flexible, compressed intravaginal ring, the process comprising:
- mixing a polymethacrylate having a glass transition temperature, a plasticizer, a thickener, and an active agent at a temperature above the glass transition temperature of the polymethacrylate to form a substantially homogeneous mixture;
- and
- compressing the substantially homogeneous mixture at a temperature below the glass transition temperature of the mixture to form a flexible, compressed intravaginal ring.
Dependencies are inferred from the claim text.