Oligodeoxynucleotide and its use to induce an immune response
AssigneeThe Gov't of USA as represented by the Secretary of the Department of Health and Human Services
InventorsDennis M. Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
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Abstract
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
Claims21
An isolated stabilized D-type oligodeoxynucleotide of no more than 30 nucleotides in length comprising the nucleic acid sequence set forth as
- 5′XXTGCGCCGATGCAGGGGGG3′;
- (SEQ ID NO:
- 18)
- 5′XXTGCATCGACGCAGGGGGG3′;
- (SEQ ID NO:
- 19)
- 5′XXTGCGTCGGTGCAGGGGGG3′;
- (SEQ ID NO:
- 20)
- 5′GGTGCATCGTTGCAGGGGGG3′;
- (SEQ ID NO:
- 30)
- or
- 5′ GGTGGATCGATCCAGGGGGG.
- (SEQ ID NO:
- 40)
Dependencies are inferred from the claim text.