Method for Producing the Flu Virus
AssigneesSanofi Pasteur Limited, Merial Limited
InventorsCatherine Gerdil, Catherine Moste, Isabelle Legastelois, Michel Marie Joseph Bublot, François-Xavier Le Gros
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Abstract
The invention relates to a method for producing flu virus according to which: a) immunizing a hen by administering a flu vaccine to the hen, b) triggering embryogenesis in one or more eggs of the immunized hen, c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs, d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus, and e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus.
Claims22
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A flu vaccine composition which comprises a flu virus or a flu virus-derived product obtained by
- a) immunizing a hen by administering a flu vaccine to the hen,
- b) triggering embryogenesis in one or more eggs of the immunized hen,
- c) infecting the one or more embryonated eggs by inoculating a flu virus into the allantoic cavity of the eggs,
- d) incubating the one or more infected embryonated eggs under temperature and humidity conditions that allow replication of the virus,
- e) harvesting the allantoic fluid of the one or more incubated eggs containing the virus,
- f) purifying the virus, and
- g) inactivating the virus.
Dependencies are inferred from the claim text.