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US 2011/0212128 A1Published application
Universal virus-like particle (VLP) influenza vaccines
AssigneeTechnoVax, Inc.
InventorsJose M. Galarza, George R. Martin
Life of this patent
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Abstract
Described herein are influenza virus-like particles (VLPs) that display on truncated, re-engineered or remodeled HA molecules on their surface. Also described are methods of making and using these VLPs.
Claims23
A virus-like particle (VLP) comprising
- at least one matrix protein;
- and
- a modified influenza HA polypeptide, wherein the modification comprises a deletion of one or more amino acid residues outside the transmembrane and cytoplasmic tail domain of the HA polypeptide.
Dependencies are inferred from the claim text.