Immunogenic peptides and uses thereof
AssigneeCancer Research Technology Limited
InventorsBarbara Ann Guinn, Nicola Rina,Mharie Hardwick
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Abstract
The present invention provides immunogenic peptides (and functional variants thereof) and their uses. The peptides comprise at least one PASD1-derived epitope. PASD1 is a cancer-testis antigen expressed in cancers, such as acute myeloid leukaemia (AML). Peptides of the invention are capable of inducing immune responses. The peptides are useful as vaccines.
Claims25
-63. (canceled)
An immunogenic peptide of 8 to 50 amino acids in length comprising at least one PASD1 epitope, wherein the epitope comprises the amino acid sequence of any one of SEQ ID NO:
- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, or 21 or a functional variant thereof.
A method of generating an immunogenic variant peptide comprising:
- (i) obtaining a parent peptide comprising at least one copy of a subsequence of PASD1 comprising any one of SEQ ID NO:
- 1, 3, 5, 7, 9, 11, or 13,
- (ii) modifying the subsequence of the parent peptide by substitution, deletion, or insertion of one or more amino acids, and
- (iii) testing the variant peptide of (ii) for immunogenicity.
Dependencies are inferred from the claim text.