MHC II Associated Protein and Uses Thereof
OwnerJohn C. Cambier, Lei Jininventors
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Abstract
The present invention provides a MHC II associated protein, MPYS, and methods for using the same. In particular, the MHC II-associated protein of the present invention mediates apoptosis and influences the susceptibility to infectious diseases. The present invention also provides methods for treating clinical conditions, methods for identifying therapeutically useful compounds using such a protein, and methods for determining susceptibility to infectious disease.
Claims14
An isolated peptide having at least 80% homology with the sequence of SEQ ID NO:1.
5-9. (canceled)
A method for identifying a compound with a potential for treating a clinical condition in which a cell expressing MPYS is required for maintenance of the clinical condition comprising:
- contacting a test compound with a protein or a cell comprising a protein having at least 80% homology with a sequence of a peptide of SEQ ID NO:1;
- and
- identifying a compounds that modulates the protein activity,
- wherein the protein activity modulation is indicative that the compound has a potential to treat the clinical condition in which a cell expressing MPYS is required for maintenance of the clinical condition.
16-23. (canceled)
A method for reducing inflammation associated with a clinical condition in a subject, said method comprising administering to the subject in need of such a treatment a compound that inhibits MPYS.
Dependencies are inferred from the claim text.