Compositions and Methods for Detecting TLR3
AssigneeInnate Pharma
InventorsKarine Chemin, Laurent Gauthier, Yannis Morel, Carine Paturel, Agnes Tisserant
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Abstract
The present invention relates to antibodies, antibody fragments, and derivatives thereof that specifically bind to TLR3 cell receptors present on the surface of cells. The invention also relates to hybridomas producing such antibodies; methods of making such antibodies; fragments, variants, and derivatives of the antibodies; pharmaceutical compositions comprising the same; methods of using the antibodies to detect TLR3 levels on the surface of cells, and the use of such antibodies and compositions for diagnostic or therapeutic purposes in subjects.
Claims15
1-48. (canceled)
A monoclonal antibody that specifically binds a human TLR3 polypeptide, wherein said antibody specifically binds to said TLR3 polypeptide in paraffin-embedded tissue sections, wherein the antibody comprises a light chain comprising the three CDRs of the 40F9 light chain variable region sequence of SEQ ID NO:3 and a heavy chain comprising the three CDRs of the 40F9 heavy chain variable region sequence of SEQ ID NO:4.
Dependencies are inferred from the claim text.