Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions

A compound of Formula (I)

• wherein
• X is CH or N,
• R1 is a hydrogen or halogen atom or CN or an C1-3 alkyl or CONH2 group,
• R2 is a straight-chained or branched C1-6 alkyl group which is independently substituted with one or two fluorine atoms, or one or two trifluoromethyl, tetrahydropyranyl, cyclopropyl, H2N—CO—, R5NHCO— or (R5)2N—CO— groups,
• wherein the above-mentioned cyclopropyl group may be substituted with one or two F or —CH2—CN,
• and wherein the two R5 groups together with the N atom to which they are attached may form a 4- to 8-membered ring, in which a carbon atom may be replaced by a O, S, SO, SO2 and/or which may be substituted with OH, NH2, N(C1-3-alkyl)2, NH(C1-3 alkyl), CF3 or C1-3-alkyl,
• or a straight-chained or branched C2-6 alkyl group which is independently substituted in position 2 to 6 with one or two hydroxy, C1-3 alkoxy, amino, CN, R5NH—, (R5)2N—, R5OCONH—, R5CONH—, R5SO2NH—, R5NHCONH— groups,
• wherein R5 is a C1-5 alkyl group, preferably a C1-4 alkyl group, more preferably Me, i-Pr or t-Bu, each optionally substituted with one CF3, NH2, NH(C1-3 alkyl), N(C1-3-alkyl)2 or MeO— group,
• an wherein the hydrogen atoms of any of the above-mentioned NH moiety may be replaced by methyl,
• R3 is a C1-2 alkyl group and
• R4 is a carboxy, C1-3alkoxy-carbonyl, —CONH2, —CONHR7, —CONH—OR7, —CONH—SO2R7 or —CO—NH-L-R6 group,
• wherein L is a —(CH2)n—, —CH2—C≡C—CH2—, or
• R6 is OH, —NH2, —NHR7, —N(R7)2, —NH—CO2R7 or a 3- to 6-membered cyclic amine such as pyrrolidine or piperidine,
• n is 2 or 3 and
• R7 is C1-4 alkyl, preferably methyl,
• or a salt thereof.