Heterocycloalkyl-containing thienopyrimidines for pharmaceutical compositions

A compound of Formula (I)

• wherein
• X is CH or N,
• R1 is H, halogen, CN, CH3 or CF3,
• R2 is a group selected from
• wherein the
• group may be substituted at the nitrogen atom by —SO2—(C1-3 alkyl), —CO—(C1-3 alkyl), —CO—(CH2)n—O—(C1-3 alkyl), —CO—(CH2)n—N(C1-3 alkyl)2, C1-4 alkyl, —(CH2)n—CF3, —(CH2)n—CHF2, —(CH2)n—OH, —(CH2)n—O—(C1-3 alkyl), —(CH2)n—CN,
• and wherein it may be substituted on a carbon atom by a —CH2OH group,
• wherein n is 1 or 2,
• and wherein the
• group may be substituted at the nitrogen atom by linear or branched C1-4 alkyl, —(CH2)n—CF3, —(CH2)n—CHF2, —(CH2)n—OH, —(CH2)n—O—(C1-3 alkyl), —(CH2)n—CN, —(CH2)n—CO—N(C1-3 alkyl)2, —SO2—(C1-3 alkyl), —CO—(C1-3 alkyl), —CO2(C1-4 alkyl), —CO2—(CH2)n—CF3, —CO2—(CH2)n—O—(C1-3 alkyl), —CO2—(CH2)n—CO—N(C1-3 alkyl)2,
• wherein n is 1 or 2,
• R3 is a C1-2 alkyl group, and
• R4 is —COOH, —CO2—(C1-3 alkyl), —CO2—(CH2)n—N(C1-3 alkyl)2, —CONH2, —CO—NHR5, —CO—NH—(CH2)p—R6, —CO—NH—(CH2)m—R7, —CO—N(CH3)—(CH2)m—R7, CO—N(CH3)—(CH2)-cyclohexyl,
• R5 is —CN, —OH, linear or branched C1-6 alkyl, —O(C1-3 alkyl), C3-6 cycloalkyl, —SO2—(C1-3 alkyl);
• pyrazolyl optionally substituted by methyl;
• or piperidinyl optionally substituted by methyl,
• wherein the C3-6 cycloalkyl group may be substituted by —NH2, —OH or —OCH3,
• R6 is —C(CH3)2Cl;
• —C(CH3)2OH;
• —CHC3-6 cycloalkyl, which is optionally substituted by OH;
• imidazolyl, which is optionally substituted by methyl;
• pyrrolidinyl, which is optionally substituted by C1-3 alkyl or by an oxo group;
• tetrahydrofuranyl;
• tetrahydropyranyl;
• phenyl, which is optionally substituted by one or two —F, —Cl, —CN, —OH, C1-3 alkyl or —O(C1-3 alkyl);
• naphthyl;
• pyridinyl;
• furanyl;
• thiophenyl;
• oxazolyl;
• thiazolyl;
• pyrazolyl;
• morpholinyl, which is optionally substituted by methyl;
• benzothiophenyl;
• —CO-phenyl;
• or —SO2—N(C1-3 alkyl)2, and
• R7 is F, —OH, —OCF3, —O—(C1-3 alkyl), —O-phenyl, —O—(CH2)m—OH, —N(C1-3 alkyl)2, —NH-phenyl, piperidinyl, pyrrolidinyl, azetedinyl or aziridinyl,
• and wherein the hydrogen atom in the NH groups may be replaced be C1-3 alkyl,
• wherein p is 1, 2 or 3, and
• m is 2 or 3,
• or a tautomer, enantionmer, diastereomer or a salt thereof.