Methods for modulating development and expansion of il-17 expressing cells
OwnerTracy Keller, Malcolm Whitman +2inventors
InventorsTracy Keller, Malcolm Whitman, Mark S. Sundrud, Anjana Rao
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Abstract
This invention provides methods and compositions for modulating the development and/or expansion of Th17 cells for use, for example, in the treatment of autoimmune diseases, persistent inflammatory diseases, infectious diseases and other Th17 related and/or IL-17 related diseases.
Claims23
A method for treating or delaying the progression of a disorder mediated by IL-17 expressing cells in a subject in need thereof, said method comprising:
- (a) identifying a patient comprising said disorder
- (b) administering to said patient a compound that selectively inhibits the development of Th17 T cells,
- wherein the compound is administered in an amount effective to inhibit the development of Th17 T cells from precursor T cells.
A composition comprising a first compound, said first compound comprising Formula I, and a second compound, wherein said second compound is selected from the group consisting of retinoic acid, an inhibitor of interleukin-21 production or activity, an inhibitor of interleukin-6 production or activity, an inhibitor of interleukin 23 production or activity, and an inhibitor of interleukin-17 production or activity.
(canceled)
A method for inducing an amino acid starvation response (AAR) in a subject in need thereof, said method comprising administering to said patient a compound that selectively inhibits the development of Th17 T cells, wherein the compound is administered in an amount effective to induce an AAR in said subject.
Dependencies are inferred from the claim text.