Methods of modulating il-22 and il-17
AssigneeWyeth
InventorsSpencer C. LIANG, Lynette A. Fouser, Margot O'Toole
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Abstract
The present application provides methods of modulating immune responses by using IL-22 in combination with at least one of IL-17A, IL-17F, or IL-23 or by using an IL-22 antagonist, such as an antibody or a soluble receptor or a binding protein, in combination with an antagonist of at least one of IL-17A, IL-17F, or IL-23
Claims23
A method of treating a disorder associated with IL-22, and at least one of IL-17A, IL-17F, or IL-23, in a subject, comprising, administering to the subject a therapeutically effective amount of a composition comprising an antagonist of IL-22, and an antagonist of at least one of IL-17A, IL-17F, or IL-23.
A method of inducing an anti-microbial peptide in a mammalian cell, comprising administering to the mammalian cell IL-22 and IL-17A, IL-22 and IL-17F, or IL-22, IL-17A, and IL-17F in an amount effective to induce an anti-microbial peptide in the mammalian cell.
A method for detecting the presence of IL-22 and at least one of IL-17A, IL-17F, or IL-23 in a sample, in vitro, comprising contacting the sample with a first reagent that binds to IL-22 and a second reagent that binds to IL-17A, IL-17F, or IL-23, and detecting formation of a first complex between the first reagent and the sample and a second complex between the second reagent and the sample, wherein detection of the first complex is indicative of the presence of IL-22 in the sample and detection of the second complex is indicative of the presence of at least one of IL-17A, IL-17F, or IL-23 in the sample.
Dependencies are inferred from the claim text.