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US 2011/0212079 A1Published application
Adaptive biochemical signatures
AssigneeOntherix, Inc.
InventorDesmond MASCARENHAS
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Abstract
The present invention is related to methods of generating adaptive biochemical signatures in live cells and the use of said signatures to identify diagnostic and therapeutic modalities for human disease. The methods described herein comprise contacting a provocative agent to live cells and measuring and analyzing adaptive readouts. The methods of the invention may be used for therapeutic or diagnostic purposes.
Claims9
A method for treating an inflammatory condition in a mammal exhibiting a biochemical signature characterized by
- (a) one or more of a physiological attribute selected from the group consisting of elevated urinary albumin, elevated urinary lipocalin-2/NGAL, and elevated plasma TNF-alpha response to inflammatory stimulus;
- and
- (b) one or more of an altered kidney gene transcript level attribute elevated B4ga1NT4, down-regulated UCHL1, and downregulated PER2;
- said method comprising treating the mammal with a therapeutic agent that disrupts the binding of Rictor to a binding partner selected from the group consisting of PRR5/Protor, Sin1, IRS1 and IRS2;
- thereby reducing or reversing the inflammatory condition.
2 more elements
Dependencies are inferred from the claim text.