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US 2011/0212068 A1Published application
Methods and compositions for treating congestive heart failure
AssigneeTheregen, Inc.
InventorsMichael Siani-Rose, Robert S. Kellar, Gail K. Naughton, Stuart K. Williams
Life of this patent
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Abstract
Compositions and methods for treating congestive heart failure are provided herein.
Claims13
1-33. (canceled)
A method of treating a human patient with congestive heart failure, comprising:
- contacting the heart tissue of a human patient with congestive heart failure with at least one cultured three-dimensional tissue,
- wherein the surface area of heart tissue that is contacted is 15 cm2 or greater;
- and
- wherein the cultured three-dimensional tissue is capable of causing heart ejection fraction to increase by 3% or more.
1 more element
A method of treating a human patient with congestive heart failure, comprising:
- contacting the heart tissue of a human patient with congestive heart failure with at least one cultured three-dimensional tissue,
- wherein the surface area of heart tissue that is contacted is 15 cm2 or greater;
- and
- wherein the cultured three-dimensional tissue is capable of causing cardiac output (CO) under stress to increase by at least about 40% over CO under rest.
1 more element
A method of treating a human patient with congestive heart failure, comprising:
- contacting the heart tissue of a human patient with congestive heart failure with at least one cultured three-dimensional tissue,
- wherein the surface area of heart tissue that is contacted is 15 cm2 or greater;
- and
- wherein the cultured three-dimensional tissue is capable of causing left ventricular ejection fraction (LVEF) under stress to increase by at least about 15% over LVEF under rest.
1 more element
A method of treating a human patient with congestive heart failure, comprising:
- contacting the heart tissue of a human patient with congestive heart failure with at least one cultured three-dimensional tissue,
- wherein the surface area of heart tissue that is contacted is 15 cm2 or greater;
- and
- wherein the cultured three-dimensional tissue is capable of causing left ventricular end diastolic volume (LVEDV) index under stress to increase by less than about 13% over LVEDV index under rest.
1 more element
A method of treating a human patient with congestive heart failure, comprising:
- contacting the heart tissue of a human patient with congestive heart failure with at least one cultured three-dimensional tissue,
- wherein the surface area of heart tissue that is contacted is 15 cm2 or greater;
- and
- wherein the cultured three-dimensional tissue is capable of causing left ventricular end systolic volume (LVESV) index under stress to decrease by at least about 47% over LVESV index under rest.
1 more element
A method of treating a human patient with congestive heart failure, comprising:
- contacting the heart tissue of a human patient with congestive heart failure with at least one cultured three-dimensional tissue,
- wherein the surface area of heart tissue that is contacted is 15 cm2 or greater;
- and
- wherein the cultured three-dimensional tissue is capable of causing systolic wall thickening under stress to increase by at least about 60% over systolic wall thickening under rest.
1 more element
Dependencies are inferred from the claim text.