Methods of manufacture of immunocompatible chorionic membrane products
OwnerSamson Tom, Alla Danilkovitch +4inventors
InventorsSamson Tom, Alla Danilkovitch, Dana Yoo, Timothy Jansen, Jin-Qiang Kuang, Jennifer Michelle Marconi
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Abstract
Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
Claims19
1-33. (canceled)
A method of manufacturing a placental product comprising the steps of:
- a. obtaining a placenta;
- b. selectively depleting the chorionic membrane of a substantial portion of one or more types of immunogenic cells, wherein
- i. the one or more types of immunogenic cells comprise trophoblasts, functional CD14+ macrophages, or both trophoblasts and functional CD14+ macrophage;
- and
- ii. the step of selective depletion does not comprise killing or removing substantially all native therapeutic cells;
- and
- c. cryopreserving the chorionic membrane in a cryopreservation medium.
Dependencies are inferred from the claim text.