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US 2011/0212057 A1Published application
Cycloundecadepsipeptide compounds and use of said compounds as a medicament
AssigneeDebio Recherche Pharmaceutique S.A.
InventorsRoland Wenger, Manfred Mutter, Patrick Garrouste, Robert Lysex, Olivier Turpin, Grégoire Vuagniaux, Valérie Nicolas, Laura Novaroli Zanolari, Rafael Crabbé
Life of this patent
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Abstract
At least one embodiment of the present invention relates to new cycloundecadepsipeptide compounds and to the use of said compounds as a medicament, in particular as antiviral agents, more particularly for preventing or treating Hepatitis C infections or HCV induced disorders.
Claims18
A cycloundecadepsipeptide compound of Formula (I)
- in which:
- AXX1 is MeBmt, 4-fluoro-MeBmt, dihydro-MeBmt, 8-hydroxy-MeBmt;
- O-acetyl-MeBmt;
- AXX2 is Abu, Val, Thr, Thr(OMe), Thr(OAc), Thr(OCOCH2CH2CH2OH), Nva, 5-hydroxy-Nva;
- AXX3 is D-MeAla, D-3-fluoro-MeAla, D-MeSer, D-MeSer(OAc), D-MeSer(OCH2CH2OH), D-MeSer(OCH2CH2NEt2), D-MeAsp(OMe);
- AXX4 is MeIle, MeMet, MeVal, MeThr, MeThr(OAc), MeAla, EtVal, EtIle, EtPhe, EtTyr, EtThr(OAc), MeThr(OAc), MeTyr, MeTyr(OAc), MeTyr(OMe), MePhe, MeMet(Ox) wherein the sulphur atom of methionine is sulphoxyde or sulphone;
- AXX5 is Leu, Val, Ile;
- AXX6 is MeAla, Sar, MeLeu;
- and
- AXX7 is Gly, Ala.
7 more elements
Dependencies are inferred from the claim text.