Methods and compositions of treating and preventing autoimmune diseases
AssigneeThe Johns Hopkins University
InventorAdam Kaplin
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Abstract
Provided are methods and compositions for treating and/or preventing an autoimmune diseases, including inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjögren's Syndrome, transplant rejection, graft vs. host disease, or host vs. graft disease.
Claims37
A method for treating or preventing an autoimmune disease, the method comprising administering to a subject in need thereof an effective amount of cyclophosphamide and anti-thymocyte globulin, wherein the autoimmune disease is inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjogren's Syndrome, transplant rejection, graft vs. host disease, or host vs. graft disease;
- and wherein the subject's immune system is reconstituted from stem cells that are continuously present in the subject following cyclophosphamide administration.
A method for treating or preventing an autoimmune disease, the method comprising administering to a subject in need thereof an effective amount of cyclophosphamide, anti-thymocyte globulin, and glatiramer acetate, wherein the autoimmune disease is inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjogren's Syndrome, transplant rejection, graft vs. host disease, or host vs. graft disease.
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A composition comprising (a) an effective amount of cyclophosphamide and anti-thymocyte globulin;
- and (b) a pharmaceutically acceptable carrier or vehicle.
A kit for treating or preventing an autoimmune disease comprising (a) one or more doses of cyclophosphamide;
- and (b) one or more doses of anti-thymocyte globulin, wherein the autoimmune disease is inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjögren's Syndrome, transplant rejection, graft vs. host disease, or host vs. graft disease.
Dependencies are inferred from the claim text.