Polymer compositions of dihydroxyacetone and uses thereof
AssigneeCornell University
InventorsDavid Putnam, Peter Zaweneh, Jason Spector
Life of this patent
Estimating the term…
Abstract
The present disclosure provides injectable synthetic and biodegradable polymeric biomaterials that effectively prevent seroma, a common postoperative complication following ablative and reconstructive surgeries. Provided biomaterials include physically crosslinked hydrogels that are thixotropic, display rapid chain relaxation, are easily extruded through narrow gauge needles, biodegrade into inert products, are well tolerated by soft tissues, and effectively prevent seroma in a radical breast mastectomy animal model.
Claims87
A method of treatment, the method comprising:
- administering a material comprising a poly-dihydroxyacetone (pDHA) copolymer at or near a wound bed or surgical site of a patient.
A method for the prevention or treatment of seromas, the method comprising the step of:
- administering a material comprising a poly-dihydroxyacetone (pDHA) copolymer at or near a wound bed or surgical site.
A method for the prevention or treatment of post-operative tissue adhesion, the method comprising the step of:
- administering a material comprising a poly-dihydroxyacetone (pDHA) copolymer at or near a wound bed or surgical site.
A method for achieving hemostasis, the method comprising the step of:
- administering a material comprising a poly-dihydroxyacetone (pDHA) copolymer at or near a wound bed or surgical site.
A copolymer comprising poly-dihydroxyacetone (pDHA), wherein the copolymer is a cross-linked hydrogel.
A copolymer comprising DHA and glycerol.
A DHA-containing copolymer comprising a first block of PEG;
- and a second block of polymer comprising DHA and glycerol.
A DHA-containing polymer comprising DHA, glycerol, and PEG.
A copolymer comprising poly-dihydroxyacetone (pDHA), wherein the copolymer is a cross-linked hydrogel comprising a repeating subunit:
- wherein:
- R3 and R4 are each independently selected from the group consisting of R5, —OR5, and —N(R5)2;
- or:
- R3 and R4 are optionally taken together with their intervening atoms to form an optionally substituted ring selected from a 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- or a 7- to 10-membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- and
- each R5 is independently hydrogen or an optionally substituted group selected from C1-20 aliphatic;
- a 3- to 7-membered saturated or partially unsaturated monocyclic carbocyclic ring;
- a 7- to 10-membered saturated or partially unsaturated bicyclic carbocyclic ring;
- phenyl;
- an 8- to 10-membered bicyclic aryl ring;
- a 3- to 7-membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- a 7- to 10-membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- an 8- to 10-membered bicyclic aryl ring;
- a 5- to 6-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
- or an 8- to 10-membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur.
Dependencies are inferred from the claim text.