Back to results
US 2011/0212034 A1Published application
Sublingual Buccal Effervescent
AssigneeCima Labs Inc.
InventorsSathasivan Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
Life of this patent
Estimating the term…
Abstract
A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
Claims9
A method of administration of fentanyl to a mammal across the oral mucosa thereof, said method comprising:
- providing a solid oral dosage form comprising fentanyl or a pharmaceutically acceptable salt thereof and at least one saliva activated effervescent couple in an amount sufficient to increase absorption of said fentanyl or pharmaceutically acceptable salt thereof across said oral mucosa, at least one pH adjusting substance, and wherein said amount of said at least one effervescent couple is between about 5% by weight and about 80% by weight;
- and buccally, sublingually or gingivally administrating said solid oral dosage form to said mammal.
Dependencies are inferred from the claim text.