Polymer particles for nir/mr bimodal molecular imaging and method for preparing the same
AssigneeKorea Research Institute of Bioscience and Biotechnology
InventorsBong Hyun Chung, Yong Taik LIm, Jung Hyun Han
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Abstract
The present invention relates to polymer particles showing magnetic properties and fluorescent properties simultaneously and a preparation method thereof More specifically, relates to polymer particles for near infrared (NIR)/magnetic resonance (MR) bimodal molecular imaging, contain a magnetic nanomaterial and an NIR fluorescent material, and a preparation method thereof The disclosed polymer particles show magnetic properties and fluorescent properties simultaneously, and thus are useful as contrast agents for NIR/MR bimodal molecular imaging.
Claims19
A method for preparing polymer particles showing magnetic properties and fluorescent properties simultaneously, the method comprising the steps of:
- (a) preparing a first dispersion (W1/O) by dispersing an aqueous solution (W1), containing a magnetic nanomaterial and an NIR fluorescent material dissolved therein, in an organic polymer solution (O), wherein any one or more of the magnetic nanomaterial and the NIR fluorescent material are hydrophilic;
- (b) preparing a second dispersion (W1/O/W2) by dispersing the first dispersion in an aqueous emulsifier solution (W2);
- and
- (c) removing the organic solvent of the organic polymer solution of the step (a) and the aqueous emulsifier solution of the step (b) by stirring and centrifuging the second dispersion, and then collecting polymer particles.
A method for preparing polymer particles showing magnetic properties and fluorescent properties simultaneously, the method comprising the steps of:
- (a) preparing a mixed solution (O) by mixing an organic solution of hydrophobic magnetic nanomaterial with an organic solution of hydrophobic NIR fluorescent material, and then adding and dissolving a polymer in the mixture;
- (b) preparing a dispersion (O/W) by dispersing the mixed solution in an aqueous emulsifier solution (W);
- and
- (c) removing the organic solvent of the organic solution of the step (a) and the aqueous emulsifier solution of the step (b) by stirring and centrifuging the dispersion, and then collecting polymer particles.
Dependencies are inferred from the claim text.