US 2011/0212028 A1 · CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS

Chemically modified cell-penetrating peptides for improved delivery of gene modulating compounds

OwnerKariem Ahmed, Samir El Andaloussi +11inventors

InventorsKariem Ahmed, Samir El Andaloussi, Peter Gutrestam, Mattias Hallbrink, Henrik Johansson, Ulo Langel, Taavi Lehto, Maria Lindgren, Imre Mager, Rannar Sillard, Katri Rosenthal Aizman, Ulf Tedebark, Per Lundin

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Abstract

The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

Claims37

Dependent claims

A system for intracellular cargo delivery comprising:

(a) at least one component A selected from the group consisting of:
(i) aliphatic linear or branched moieties with at least 4 carbon atoms, and
(ii) cyclic ring systems comprising 2-4 rings, which may contain several hetero atoms selected from the group consisting of N, S, O and P;
and
(b) a cell penetrating peptide B and/or a non-peptide analog thereof;
wherein said at least one component A is attached to said peptide B and/or non-peptide analog thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/119,398Filed 16 Sep 2009

Priority

16 Sep 2008

Published

1 Sep 2011

Term ends

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Classification23 codes

A61K 49/0004
Preparations for testing in vivo: screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance,…
A61K 31/20
Carboxylic acids, e.g. valproic acid: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
A61K 47/543
The modifying agent being an organic compound: lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
A61K 47/641
Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is…:…