Process for producing pellets for pharmaceutical compositions
AssigneeTemrel Limited
InventorsChristopher SPEIRS, Peter Moir, Richard Williams, Michael Clark
Life of this patent
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Abstract
Water is used to control particle size in a process comprising mixing water with a composition comprising a rheology modifying agent and possibly sugar and cellulose to produce a paste. The paste is extruded to form particles which are then spheronised and dried. One advantage of using water to control particle size is that the number of particles having a diameter within a required range, e.g. between from about 800 to about 1500 μm, may be increased.
Claims23
A process for producing particles of controlled size and size distribution for use in a pharmaceutical composition, comprising the steps of:
- (a) admixing water with a component composition to produce a paste, the component composition comprising at least a rheology modifying agent in an amount effective to form on hydration a matrix with visco-elastic property;
- (b) extruding at least a portion of the paste to form extrudate;
- (e) spheronising at least a portion of the extrudate to form spheronised particles;
- and
- (d) drying at least a portion of the spheronised particles
- wherein the amount of water added in step (a) is admixed in an amount of between from about 180 wt % to about 190 wt % of the component composition so as to provide said spheronized particles in step (d) having a particle size distribution such that from about 80% to about 98% of the particles have a diameter from about 800 to about 1500 μm.
A process for producing particles of controlled size and size distribution for use in a pharmaceutical composition, comprising the steps of:
- (a) admixing water with a component composition to produce a paste, the component composition comprising at least a rheology modifying agent in an amount effective to form on hydration a matrix with visco-elastic property;
- (b) extruding at least a portion of the paste to form extrudate;
- (c) spheronising at least a portion of the extrudate to form spheronised particles;
- and
- (d) drying at least a portion of the spheronised particles, wherein the amount of water added in step (a) is admixed in an amount of between from about 180 wt % to about 190 wt % of the component composition so as to provide said spheronized particles in step (d) having a particle size distribution such that from about 90% to about 98% of the particles have a diameter from about 800 to about 1500 μm.
A process for producing particles of controlled size and size distribution for use in a pharmaceutical composition, comprising the steps of:
- (a) admixing water with a component composition to produce a paste, the component composition comprising at least a rheology modifying agent in an amount effective to form on hydration a matrix with visco-elastic property;
- (b) extruding at least a portion of the paste to form extrudate;
- (c) spheronising at least a portion of the extrudate to form spheronised particles;
- and
- (d) drying at least a portion of the spheronised particles,
- wherein the amount of water added in step (a) is admixed in an amount of between from about 180 wt % to about 190 wt % of the component composition so as to provide said spheronized particles in step (d) having a particle size distribution such that from about 95% to about 98% of the particles have a diameter from about 800 to about 1500 μm.
Dependencies are inferred from the claim text.