Metastable CID
OwnerSteven M. Colby, O. David Sparkmaninventors
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Abstract
Systems and methods of generating ions at atmospheric pressure are presented. These systems and methods include spatially dependent analysis of a sample using an effusive ionization source. Systems and methods of isolating samples at atmospheric pressure are presented. These systems and methods include using a barrier to prevent metastables or electrons from an effusive ion source from reaching a sample unless the sample is in an analysis position. Systems and methods of using metastables in collisionally induced dissociation are presented.
Claims32
A system comprising:
- a first analyzer configured to analyze ions according to their m/z values;
- an effusive source of excited metastables;
- and
- a collision induced dissociation region configured to receive the excited metastables, and configured to facilitate collisions between the ions and the excited metastables, the collisions resulting in generation of product ions from the ions.
The system of claim, wherein the first m/z analyzer is further configured to analyze the product ions.
A system comprising:
- an effusive metastable source configured to generate metastables;
- a first m/z analyzer configured to separate ions according to m values;
- a collision induced dissociation region configured to receive the separated ions and the metastables;
- a second m/z analyzer configured to receive product ions generated through collisions between the separated ions and the metastables, and to separate the product ions according to their m/z values;
- and
- a detector configured to detect the separated product ions.
A method comprising:
- generating excited metastables;
- generating first ions;
- separating the first ions to produce separated ions;
- colliding the separated ions with the metastables to produce product ions;
- and
- separating the product ions.
A system comprising:
- a passageway configured for a person or an article to pass through;
- at least one metastable source configured to generate metastable species;
- a first MS inlet configured to receive ions generated as a result of the metastable species striking the person or the article as the person or the article passes through the passageway;
- and
- at least one mass spectrometer configured to receive the ions from the first MS inlet.
Dependencies are inferred from the claim text.