Enhanced Resolution Mass Spectrometer and Mass Spectrometry Method
OwnerAugust Hidalgo, John Fjeldsted +1inventors
InventorsAugust Hidalgo, John Fjeldsted, William Frazer
Life of this patent
Estimating the term…
Abstract
A mass spectrum is generated by a process in which, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak is selected. One or more synthesized samples are synthesized from the subset of the original samples. The one or more synthesized samples provide a temporal resolution greater than the temporal resolution of the original samples. The one or more synthesized samples are summed with respective temporally-aligned accumulated samples to produce the mass spectrum. The accumulated samples are obtained from mass scan signals generated during respective previously-performed mass scan operations.
Claims27
A method for generating a mass spectrum, the method comprising:
- from a mass scan signal comprising original samples defining a peak, selecting a subset of the original samples defining the peak, the original samples having a temporal resolution;
- synthesizing from the subset of the original samples one or more synthesized samples providing a temporal resolution greater than the temporal resolution of the original samples;
- and
- summing the one or more synthesized samples with respective temporally-aligned accumulated samples to produce the mass spectrum, the accumulated samples obtained from mass scan signals generated during respective previously-performed mass scan operations.
A mass spectrometer, comprising:
- a sample selector operable to select, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak, the original samples having a temporal resolution;
- a sample synthesizer operable to synthesize from the subset of the original samples one or more synthesized samples providing a temporal resolution greater than the temporal resolution of the original samples;
- and
- a sample combiner operable to sum the one or more synthesized samples with respective temporally-aligned accumulated samples to produce a mass spectrum, the accumulated samples generated by the sample selector, the sample synthesizer and the sample summer from mass scan signals obtained during respective previously-performed mass scan operations.
A computer-readable medium in which is fixed a program operable to cause a computational device to perform a method that generates a mass spectrum, the method comprising:
- selecting, from a mass scan signal comprising original samples defining a peak, a subset of the original samples defining the peak, the original samples having a temporal resolution;
- synthesizing from the subset of the original samples one or more synthesized samples providing a temporal resolution greater than the temporal resolution of the original samples;
- and
- summing the one or more synthesized samples with respective temporally-aligned accumulated samples to produce the mass spectrum, the accumulated samples obtained from mass scan signals generated during respective previously-performed mass scan operations.
Dependencies are inferred from the claim text.