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US 2011/0201984 A1Published application
Medical Device Applications of Nanostructured Surfaces
AssigneeNanosys, Inc.
InventorsRobert S. Dubrow, Lawrence A. Bock, R. Hugh Daniels, Veeral D. Hardev, Chunming Niu, Vijendra Sahi
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Abstract
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
Claims29
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein the wound dressing is flexible;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein the wound dressing is air-penetrable;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein the wound dressing is water-repellent;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein the wound dressing adheres to both dry surfaces and wet surfaces;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein the wound dressing does not chemically bond to the biological tissue surface;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein at least a portion of the plurality of nanostructures are bent, curved, curled, or coiled;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein at least a portion of the plurality of nanostructures have an average length of from about 1 nm to at least about 500 microns;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein at least a portion of the plurality of nanostructures comprise nanowires which have a substantially uniform diameter along the length of the nanowire;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein at least a portion of the plurality of nanostructures comprise nanowires which have a non-uniform diameter along the length of the nanowire;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein a first portion of the plurality of nanostructures have a different size and/or shape than a second portion of the plurality of nanostructures;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein at least a portion of the plurality of nanostructures protrude at least 10 nm above a first surface of the wound dressing;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein at least a portion of the plurality of nanostructures comprises an average density on one or more surfaces of the wound dressing from about 50 nanostructures per square micron to at least about 100 nanostructures per square micron;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
A wound dressing comprising:
- a plurality of nanostructures;
- and
- a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
- wherein the fibrous web includes a woven or non-woven fibrous mat;
- and
- wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
3 more elements
Dependencies are inferred from the claim text.