Products and methods to prevent infections

A method for producing synthetically multimerised immunoglobulins comprising the steps of

• i. providing a starting material
• ii. isolating immunoglobulin, part or fragments thereof
• iii. multimerising the isolated immunoglobulin of step ii)
• iv. obtaining multimerised immunoglobulin
• or
• v) providing a starting material
• vi) mulimerising components of the starting material of step v)
• vii) optionally, isolating immunoglobulin, part or fragments thereof
• viii) obtaining multimerised immunoglobulin

A pharmaceutical composition comprising the composition selected from

• (a) a composition comprising immunoglobulins, part or fragments thereof, wherein said immunoglobulins are synthetically multimerised, and wherein, optionally,
• (i) said synthetically multimerised immunoglobulins comprise at least one cross-linking covalent chemical bond between individual immunoglobulins, or
• (ii) said composition comprises at least 15% synthetically multimerised immunoglobulin, part or fragment thereof;
• or
• (b) a composition obtainable by a method for producing synthetically multimerised immunoglobulins comprising the steps of
• i. providing a starting material
• ii. isolating immunoglobulin, part or fragments thereof
• iii. multimerising the isolated immunoglobulin of step ii)
• iv. obtaining multimerised immunoglobulin
• or
• v) providing a starting material
• vi) mulimerising components of the starting material of step v)
• vii) optionally, isolating immunoglobulin, part or fragments thereof
• viii) obtaining multimerised immunoglobulin;
• wherein, optionally,
• said starting material is selected from milk, colostrum, whey, serum, plasma and eggs, or a part thereof;
• and/or
• said multimerisation of step iii) and/or step vi) involves cross-linking of the immunoglobulins of step ii), and/or the components of the starting material of step v);
• and, optionally, said cross-linking is obtained by use of periodate or a periodate forming compound;
• and
• wherein, optionally, said composition further comprises germ free colostrum, or a part or fragment thereof, and wherein said germ free colostrum, or part or fragment thereof, is optionally obtainable by a method comprising the steps of
• i) providing colostrum, part or derivative thereof
• ii) mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, his naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• iii) obtaining a composition that is free of pathogenic microorganisms;
• and optionally a pharmaceutically acceptable carrier.

A method for treating an individual in need thereof with a composition selected from the group consisting of:

• (a) a composition comprising immunoglobulins, part or fragments thereof, wherein said immunoglobulins are synthetically multimerised, and wherein, optionally,
• (i) said synthetically multimerised immunoglobulins comprise at least one cross-linking covalent chemical bond between individual immunoglobulins, or
• (ii) said composition comprises at least 15% synthetically multimerised immunoglobulin, part or fragment thereof;
• (b) a composition obtainable by a method for producing synthetically multimerised immunoglobulins comprising the steps of
• i. providing a starting material
• ii. isolating immunoglobulin, part or fragments thereof
• iii. multimerising the isolated immunoglobulin of step ii)
• iv. obtaining multimerised immunoglobulin
• or
• v) providing a starting material
• vi) mulimerising components of the starting material of step v)
• vii) optionally, isolating immunoglobulin, part or fragments thereof
• viii) obtaining multimerised immunoglobulin;
• wherein, optionally,
• said starting material is selected from milk, colostrum, whey, serum, plasma and eggs, or a part thereof;
• and/or
• said multimerisation of step iii) and/or step vi) involves cross-linking of the immunoglobulins of step ii), and/or the components of the starting material of step v);
• and, optionally, said cross-linking is obtained by use of periodate or a periodate forming compound;
• and
• wherein, optionally, said composition further comprises germ free colostrum, or a part or fragment thereof, and wherein said germ free colostrum, or part or fragment thereof, is optionally obtainable by a method comprising the steps of
• i) providing colostrum, part or derivative thereof
• ii) mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• iii) obtaining a composition that is free of pathogenic microorganisms;
• (c) a composition free from pathogenic microorganisms, said composition being obtainable by a method for producing a germ free composition, comprising the steps of
• providing colostrum, part or derivative thereof
• mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• obtaining a composition that is free of pathogenic microorganisms,
• wherein optionally said colostrum, part or derivative thereof in a further step is multimerised by at least one cross-linking agent;
• and
• (d) a pharmaceutical composition comprising the composition of (a) or (b) and optionally a pharmaceutically acceptable carrier;
• said method comprising the step of administering to said individual said composition of (a), (b), (c), or (d) in the form of one or more of a food supplement, a dietary composition, an infant formulation, a growth promoter and a milk replacer.

A method for preventing, ameliorating and/or treating a pathogenic infection in an individual in need thereof, said method comprising the steps of providing the composition selected from the group consisting of:

• (a) a composition comprising immunoglobulins, part or fragments thereof, wherein said immunoglobulins are synthetically multimerised, and wherein, optionally,
• (i) said synthetically multimerised immunoglobulins comprise at least one cross-linking covalent chemical bond between individual immunoglobulins, or
• (ii) said composition comprises at least 15% synthetically multimerised immunoglobulin, part or fragment thereof;
• (b) a composition obtainable by a method for producing synthetically multimerised immunoglobulins comprising the steps of
• i. providing a starting material
• ii. isolating immunoglobulin, part or fragments thereof
• iii. multimerising the isolated immunoglobulin of step ii)
• iv. obtaining multimerised immunoglobulin
• or
• v) providing a starting material
• vi) mulimerising components of the starting material of step v)
• vii) optionally, isolating immunoglobulin, part or fragments thereof
• viii) obtaining multimerised immunoglobulin;
• wherein, optionally,
• said starting material is selected from milk, colostrum, whey, serum, plasma and eggs, or a part thereof;
• and/or
• said multimerisation of step iii) and/or step vi) involves cross-linking of the immunoglobulins of step ii), and/or the components of the starting material of step v);
• and, optionally, said cross-linking is obtained by use of periodate or a periodate forming compound;
• and
• wherein, optionally, said composition further comprises germ free colostrum, or a part or fragment thereof, and wherein said germ free colostrum, or part or fragment thereof, is optionally obtainable by a method comprising the steps of
• i) providing colostrum, part or derivative thereof
• ii) mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• iii) obtaining a composition that is free of pathogenic microorganisms;
• (c) a composition free from pathogenic microorganisms, said composition being obtainable by a method for producing a germ free composition, comprising the steps of
• providing colostrum, part or derivative thereof
• mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• obtaining a composition that is free of pathogenic microorganisms,
• wherein optionally said colostrum, part or derivative thereof in a further step is multimerised by at least one cross-linking agent;
• and
• (d) a pharmaceutical composition comprising the composition of (a) or (b) and optionally a pharmaceutically acceptable carrier;
• and administering the composition of (a), (b), (c), or (d) to said individual.

A method for passively immunising an individual, said method comprising the steps of providing a composition selected from the group consisting of:

• (a) a composition comprising immunoglobulins, part or fragments thereof, wherein said immunoglobulins are synthetically multimerised, and wherein, optionally,
• (i) said synthetically multimerised immunoglobulins comprise at least one cross-linking covalent chemical bond between individual immunoglobulins, or
• (ii) said composition comprises at least 15% synthetically multimerised immunoglobulin, part or fragment thereof;
• (b) a composition obtainable by a method for producing synthetically multimerised immunoglobulins comprising the steps of
• i. providing a starting material
• ii. isolating immunoglobulin, part or fragments thereof
• iii. multimerising the isolated immunoglobulin of step ii)
• iv. obtaining multimerised immunoglobulin
• or
• v) providing a starting material
• vi) mulimerising components of the starting material of step v)
• vii) optionally, isolating immunoglobulin, part or fragments thereof
• viii) obtaining multimerised immunoglobulin;
• wherein, optionally,
• said starting material is selected from milk, colostrum, whey, serum, plasma and eggs, or a part thereof;
• and/or
• said multimerisation of step iii) and/or step vi) involves cross-linking of the immunoglobulins of step ii), and/or the components of the starting material of step v);
• and, optionally, said cross-linking is obtained by use of periodate or a periodate forming compound;
• and
• wherein, optionally, said composition further comprises germ free colostrum, or a part or fragment thereof, and wherein said germ free colostrum, or part or fragment thereof, is optionally obtainable by a method comprising the steps of
• i) providing colostrum, part or derivative thereof
• ii) mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• iii) obtaining a composition that is free of pathogenic microorganisms;
• (c) a composition free from pathogenic microorganisms, said composition being obtainable by a method for producing a germ free composition, comprising the steps of
• providing colostrum, part or derivative thereof
• mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• obtaining a composition that is free of pathogenic microorganisms,
• wherein optionally said colostrum, part or derivative thereof in a further step is multimerised by at least one cross-linking agent;
• and
• (d) a pharmaceutical composition comprising the composition of (a) or (b) and optionally a pharmaceutically acceptable carrier;
• and administering the composition of (a), (b), (c), or (d) to said individual for passive immunisation.

A method for prevention, amelioration and/or treating an infection in an individual suffering from a disease suppressing the immune system, said method comprising the steps of providing a composition selected from the group consisting of:

• (a) a composition comprising immunoglobulins, part or fragments thereof, wherein said immunoglobulins are synthetically multimerised, and wherein, optionally,
• (i) said synthetically multimerised immunoglobulins comprise at least one cross-linking covalent chemical bond between individual immunoglobulins, or
• (ii) said composition comprises at least 15% synthetically multimerised immunoglobulin, part or fragment thereof;
• (b) a composition obtainable by a method for producing synthetically multimerised immunoglobulins comprising the steps of
• i. providing a starting material
• ii. isolating immunoglobulin, part or fragments thereof
• iii. multimerising the isolated immunoglobulin of step ii)
• iv. obtaining multimerised immunoglobulin
• or
• v) providing a starting material
• vi) mulimerising components of the starting material of step v)
• vii) optionally, isolating immunoglobulin, part or fragments thereof
• viii) obtaining multimerised immunoglobulin;
• wherein, optionally,
• said starting material is selected from milk, colostrum, whey, serum, plasma and eggs, or a part thereof;
• and/or
• said multimerisation of step iii) and/or step vi) involves cross-linking of the immunoglobulins of step ii), and/or the components of the starting material of step v);
• and, optionally, said cross-linking is obtained by use of periodate or a periodate forming compound;
• and
• wherein, optionally, said composition further comprises germ free colostrum, or a part or fragment thereof, and wherein said germ free colostrum, or part or fragment thereof, is optionally obtainable by a method comprising the steps of
• i) providing colostrum, part or derivative thereof
• ii) mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• iii) obtaining a composition that is free of pathogenic microorganisms;
• (c) a composition free from pathogenic microorganisms, said composition being obtainable by a method for producing a germ free composition, comprising the steps of
• i) providing colostrum, part or derivative thereof
• ii) mixing the colostrum of step i) with at least one disinfectant dye selected from the group consisting of methylene blue and related thionine dyes, acridine orange, acridine yellow and related acriflavine (acridine) dyes, proflavine hemisulphate, quinacrine and its derivatives, brilliant green, gentian violet, crystal violet and related triphenyl methane dyes, bis naphthalene dyes such as trypan blue and trypan red, and/or combinations thereof
• iii) obtaining a composition that is free of pathogenic microorganisms,
• wherein optionally said colostrum, part or derivative thereof in a further step is multimerised by at least one cross-linking agent;
• and
• (d) a pharmaceutical composition comprising the composition of (a) or (b) and optionally a pharmaceutically acceptable carrier;
• and administering the composition of (a), (b), (c), or (d) to said individual, thereby preventing, ameliorating and/or treating the infection in the individual suffering from a disease suppressing the immune system.