Method and assembly for measuring thrombin generation in plasma
AssigneeSynapse, Inc.
InventorsHendrik Coenraad Hemker, Rafael Jesus Apitz-Castro, Sebastiaan Nijhuis
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Abstract
Disclosed is a method for measuring thrombin generation in a whole blood sample. The whole blood sample may be applied forthwith, without prior processing. The blood cells and blood plasma in the whole blood sample are separated by (lateral) flow migration. Also disclosed is an assembly of a sample support and a device dedicated to measure thrombin generation in a whole blood sample. Advantageously, the sample support comprises a separator medium allowing separation of whole blood into blood cells and blood plasma by means of (lateral) flow migration.
Claims19
An assembly comprising a sample support and a device for measuring thrombin generation in blood plasma, wherein
- (a) the device comprises a housing having a light tight box having a cartridge retainer received therein and wherein at least a part of a light source and a part of a light sensor are directed towards said cartridge retainer, said light tight box having a insertion opening for inserting the sample support and for directing the sample support into a receiving space for a sample holder in the cartridge retainer, and
- (b) the sample support comprises a longitudinal separator medium having a sampling area near one end of the separator medium and a reading area near the other end of the separator medium, said other end being receivable in the insertion opening and the receiving space.
The assembly according to claim 3, wherein the separator medium is made of cellulose or a cellulose derivative.
A method for measuring thrombin generation in a whole blood sample, comprising separating, immediately after induction of thrombin generation, blood cells from plasma by means of flow migration of the plasma with retention of the cells.
Dependencies are inferred from the claim text.