Loading patent…
AssigneeThe Johns Hopkins University
InventorsPaul Frederic Worley, Guo-li Ming, Joseph P. Steiner
Estimating the term…
The present invention is based on the discovery of a novel function of an FKBP proline isomerases in chemotropic nerve guidance and axon regeneration through gating of TRPC1 channel activity. Accordingly, there are provided methods for identifying an agent that inhibits FKBP52 binding to TRPC1. Also provided are methods for identifying an inhibitor of an FKBP52-TRPC1 signaling pathway by contacting a cell expressing TRPC1 and FKBP52 with a test agent and detecting a change in agonist-induced calcium flux of TRPC1. Further provided are methods of enhancing axonal outgrowth by inhibiting the activity of FKBP52 in a neuronal growth cone, and methods of enhancing axonal regeneration in a subject in need thereof by administering an agent that inhibits the activity of FKBP52.
A method of identifying an agent that inhibits FKBP52 binding to TRPC1 comprising:
A method of detecting or identifying an inhibitor of an FKBP52-TRPC1 signaling pathway comprising:
A method of enhancing axonal outgrowth comprising:
A method of enhancing axonal outgrowth in a subject in need thereof comprising:
Dependencies are inferred from the claim text.