Pyrimidyl cyclopentanes as akt protein kinase inhibitors

A compound of Formula I:

• and enantiomers and salts thereof, wherein:
• R1 and R1a are independently selected from H, Me, Et, vinyl, CF3, CHF2 or CH2F;
• R2 is H, OH, OMe or F;
• R2a is H, Me or F;
• R3 is H, Me, Et, or CF3;
• A is
• G is phenyl optionally substituted by one to four Re groups or a 5-6 membered heteroaryl optionally substituted by a halogen;
• R5 and R6 are independently H, OCH3, C3-C6-cycloalkyl optionally substituted with F, OH, C1-C3 alkyl or O(C1-C3 alkyl), 4-6 membered heterocycle optionally substituted with F, OH, C1-C3 alkyl, cyclopropylmethyl or C(═O)(C1-C3 alkyl), or C1-C6-alkyl optionally substituted with one or more groups independently selected from OH, oxo, O(C1-C6-alkyl), CN, F, NH2, NH(C1-C6-alkyl), N(C1-C6-alkyl)2, cyclopropyl, phenyl, imidazolyl, piperidinyl, pyrrolidinyl, morpholinyl, tetrahydrofuranyl, oxetanyl or tetrahydropyranyl,
• or R5 and R6 together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring optionally substituted with one or more groups independently selected from OH, halogen, oxo, CF3, CH2CF3, CH2CH2OH, O(C1-C3 alkyl), C(═O)CH3, NH2, NHMe, N(Me)2, S(O)2CH3, cyclopropylmethyl and C1-C3 alkyl, or
• Rc is hydrogen and Rd and R6 together with the atoms to which they are attached form a 4 to 6 membered heterocyclic ring having one nitrogen atom;
• Ra and Rb are H,
• or Ra is H, and Rb and R6 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having one or two ring nitrogen atoms;
• Rc and Rd are H or Me,
• or Rc and Rd together with the atom to which they are attached from a cyclopropyl ring;
• each Re is independently halogen, C1-C6-alkyl, C3-C6-cycloalkyl, O—(C1-C6-alkyl), CF3, OCF3, S(C1-C6-alkyl), CN, OCH2-phenyl, NH2, NO2, NH—(C1-C6-alkyl), N—(C1-C6-alkyl)2, piperidine, pyrrolidine, CH2F, CHF2, OCH2F, OCHF2, OH, SO2(C1-C6-alkyl), C(O)NH2, C(O)NH(C1-C6-alkyl), and C(O)N(C1-C6-alkyl)2;
• m and n are independently 0, 1, 2 or 3 with the proviso that (m+n) must equal 2, 3 or 4;
• and
• p is 0 or 1.