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US 2011/0098350 A1Published application
Substituted cyclohexylidene-ethylidene-octahydro-indene compounds
AssigneeBen-Gurion University of the Negev Research and Development Authority
InventorsShimon Ben Shabat, Amnou Sintov
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Abstract
Novel substituted cyclohexylidene-ethylidene-octahydro-indene compounds and compositions comprising the same are described. The compounds exhibit profound anti-proliferative effects, in comparison to other compounds known for their anti-cancer and anti-hyperproliferative ability. Methods of use of such compounds and compositions are described for treating a variety of cancers, inflammatory and other hyperproliferative diseases and disorders.
Claims27
A compound of formula I:
- Wherein:
- R1 and R2 are independently H, C(1-4) alkyl, halogen, cycloalkyl;
- R3 and R4 are independently OH, OAlk, Alk denoting a C(1-4) alkyl group, halogen, CN, NH2, NO2, C(1-4) alkylene, haloalkyl.
- L is carbon and optionally forms a double bond with P or with X, or L forms an epoxide with P.
- P is carbon and optionally forms a double bond with L or M, or P forms an epoxide with L or M or P is O;
- Q is nothing, or a carbonyl;
- M is an alkylene (C1-C4), or optionally a carbon which forms a double bond with P, or M forms an epoxide with P.
- Y is nothing, H, OH, OAlk, Alk denoting a C(1-4) alkyl group, O—CO-alkyl.
- X is H, oxo, OH, or halogen, OAlk, Alk denoting a C(1-4) alkyl group, O—CO-alkyl.
- Z is H, oxo, OH or halogen, OAlk, Alk denoting a C(1-4) alkyl group, O—CO-alkyl.
- Or L, P, M, Z and X forms a saturated or unsaturated 5-7 membered, carbocyclic or heterocyclic ring, wherein L, P, M are defined as above and X and Z are independently O, N, S or C.
8 more elements
A composition comprising the compound of formula 1.
15-22. (canceled)
(canceled)
Dependencies are inferred from the claim text.