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US 2011/0091501 A1Published application
Recombinant Rhinovirus Vectors
AssigneeSanofi Pasteur Biologics, LLC
InventorsKirill Kalnin, Yanhua Yan, Maryann Giel-Moloney, Harold Kleanthous
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Abstract
The invention provides rhinovirus vectors, which can be used in the delivery of immunogens, such as influenza virus immunogens, and corresponding compositions and methods.
Claims30
A rhinovirus vector comprising an influenza virus HA0 immunogen.
A NimII peptide comprising an inserted influenza virus HAO immunogen.
A method of generating a rhinovirus vector comprising an influenza virus HA0 immunogen, the method comprising the steps of:
- (i) generating a library of recombinant rhinovirus vectors based on an infectious cDNA clone that comprises inserted influenza virus HA0 immunogen sequences, and
- (ii) selecting from the library recombinant viruses that (a) maintain inserted sequences upon passage, and (b) are neutralized with antibodies against the inserted sequence.
(canceled)
Dependencies are inferred from the claim text.