Vaccine compositions and uses thereof
AssigneeNorthwestern University
InventorsMansour Moahamadzadeh, Todd R. Klaenhammer
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Abstract
The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comprising an antigen and a dendritic cell-targeting peptide. Such compositions target vaccines to dendritic cells, resulting in a high level of humoral and acquired immunity, including both mucosal and systemic immunity. Such delivery systems find use in the specific delivery of a wide variety of oral vaccines to subjects.
Claims13
A composition comprising a nucleic acid encoding a fusion polypeptide comprising a dendritic cell-targeting peptide fused to an antigen of interest.
An immunization method, comprising
- administering a composition comprising a bacteria comprising a nucleic acid encoding a fusion polypeptide comprising a dendritic cell-targeting peptide fused to an antigen of interest to a subject,
- wherein said administering confers immunity to said antigen to said subject.
Dependencies are inferred from the claim text.