Novel vaccine for dog
AssigneeNippon Zenyaku Kogyo Co., Ltd.
InventorsMasayuki Okazaki, Takahiro Yoshimura, Toshihiro Tsukui, Shigehiro Iwabuchi
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Abstract
This invention provides vaccines against canine distemper virus infections, canine adenovirus type 2 infections, and canine parvovirus infections that can be orally administered. The invention also provides the attenuated canine distemper virus strain obtained by adapting the canine distemper virus 95-54 strains in cultured cells to attenuate the same, the attenuated canine adenovirus type 2 strain obtained by adapting the canine adenovirus type 2 F1 strain in cultured cells to attenuate the same, and an attenuated canine parvovirus strain obtained by adapting the canine parvovirus F3 strain in cultured cells to attenuate the same.
Claims23
A canine parvovirus F3 strain having a VP2 gene comprising the nucleotide sequence as shown in SEQ ID NO:
- 1 or a nucleotide sequence derived from the nucleotide sequence as shown in SEQ ID NO:
- 1 by deletion, substitution, or addition of one or several nucleotides.
A canine adenovirus type 2 μl strain having an LITR E1A2 gene consisting of the nucleotide sequence as shown in SEQ ID NO:
- 5 or a nucleotide sequence derived from the nucleotide sequence as shown in SEQ ID NO:
- 5 by deletion, substitution, or addition of one or several nucleotides and having an RITR gene consisting of the nucleotide sequence as shown in SEQ ID NO:
- 7 or a nucleotide sequence derived from the nucleotide sequence as shown in SEQ ID NO:
- 7 by deletion, substitution, or addition of one or several nucleotides.
The canine adenovirus type 2 F1 strain deposited at the European Collection of Cell Cultures (ECACC) under Accession Number 07071601.
A canine distemper virus 95-54 strain having an H gene consisting of the nucleotide sequence as shown in SEQ ID NO:
- 9 or a nucleotide sequence derived from the nucleotide sequence as shown in SEQ ID NO:
- 9 by deletion, substitution, or addition of one or several nucleotides and having an F gene consisting of the nucleotide sequence as shown in SEQ ID NO:
- 12 or a nucleotide sequence derived from the nucleotide sequence as shown in SEQ ID NO:
- 12 by deletion, substitution, or addition of one or several nucleotides.
The canine distemper virus 95-54 strain deposited at the European Collection of Cell Cultures (ECACC) under Accession Number 07071602.
Dependencies are inferred from the claim text.