Process, software arrangement and computer-accessible medium for obtaining information associated with a haplotype

A process for determining Restriction Fragment Length Polymorphism (“RFLP”) haplotypes of heterozygous RFLP markers for a single individual of a diploid organism based on DNA of the single individual, comprising:

• a. receiving data comprising ordered restriction maps of pieces of single DNA molecules of the single individual (a “first ordered restriction map set”);
• b. combining at least one pair of maps from the first ordered restriction map set based on at least one overlap between ends of the maps to generate one or more further ordered restriction maps (a “second ordered restriction map set”);
• c. identifying the heterozygous RFLP markers in the DNA of the single individual based on an alignment between maps in the first ordered restriction map set and maps in the second ordered restriction map set;
• d. using a processing arrangement, computing information for phasing of neighboring pairs of the heterozygous RFLP markers;
• and
• e. determining the RFLP haplotypes based on the computed information.

A system for determining Restriction Fragment Length Polymorphism (“RFLP”) haplotypes of heterozygous RFLP markers for a single individual of a diploid organism based on DNA of the single individual, comprising:

• a processing arrangement that, when executed, is configured to:
• a. receive data comprising ordered restriction maps of pieces of single DNA molecules of the single individual (a “first ordered restriction map set”);
• b. combine at lease one pair of maps from the first ordered restriction map set based on at least one overlap between ends of the maps to generate one or more further ordered restriction maps (a “second ordered restriction map set”);
• c. identify the heterozygous RFLP markers in the DNA of the single individual based on an alignment between maps in the first ordered restriction map set and maps in the second ordered restriction map set;
• d. compute information for phasing of neighboring pairs of the heterozygous RFLP markers;
• and
• e. determine the RFLP haplotypes based on the computed information.

A computer-accessible medium having stored thereon computer executable instructions for determining Restriction Fragment Length Polymorphism (“RFLP”) haplotypes of heterozygous RFLP markers for a single individual of a diploid organism based on DNA of the single individual, which, when the executable instructions are executed by a processing arrangement, configure the processing arrangement to:

• a. receive data comprising ordered restriction maps of pieces of single DNA molecules of the single individual (a “first ordered restriction map set”);
• b. combine at least one pair of maps from the first ordered restriction map set based on at least one overlap between ends of the maps to generate one or more further ordered restriction maps (a “second ordered restriction map set”);
• c. identify the heterozygous RFLP markers in the DNA of the single individual based on an alignment between maps in the first ordered restriction map set and maps in the second ordered restriction map set;
• d. compute information for phasing of neighboring pairs of the heterozygous RFLP markers;
• and
• e. determine the RFLP haplotypes based on the computed information.