Transmucosal drug delivery device and method including chemical permeation enhancers

A method for local transmucosal delivery of a drug to a human or animal subject comprising:

• deploying a drug delivery device within a mucosal tissue lumen;
• releasing from, or generating with, the device a permeability enhancing substance such that the permeability enhancing substance contacts a region of the mucosal tissue;
• and
• dispensing from the drug delivery device a drug by a positive displacement process such that the drug is delivered to the region of the mucosal tissue that is contacted by the permeability enhancing substance.

An intravaginal device for transmucosal drug delivery comprising:

• a housing configured for intravaginal deployment into a human or animal subject;
• a drug dispenser containing a drug, the drug dispenser having one or more nozzles and a positive displacement element adapted to dispense the drug from the housing through the one or more nozzles by positive displacement;
• and
• a permeability enhancer dispenser configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intravaginally deployed in the human or animal subject,
• wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.