Transmucosal drug delivery device and method including electrically-actuated permeation enhancement
AssigneePalo Alto Research Center Incorporated
InventorsScott Uhland, Eric Peeters, Serena Wong
Life of this patent
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Abstract
Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.
Claims27
An intralumenal device for transmucosal drug delivery comprising:
- a housing configured for intralumenal deployment into a human or animal subject;
- a drug-dispensing portion which contains at least one drug;
- and
- an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject,
- wherein the device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.
A method for local transmucosal delivery of a drug to a human or animal subject comprising:
- deploying a drug delivery device within a mucosal tissue lumen, the device comprising a housing and an electrically-actuatable portion;
- actuating the electrically-actuatable portion to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time following the insertion;
- and
- administering at least one drug through a region of the disrupted mucosal barrier.
An intravaginal device for transmucosal drug delivery comprising:
- a housing configured for intravaginal deployment into a human or animal subject;
- an electrically-actuatable portion comprising one or more electrically-actuatable active disruption elements configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally inserted into the human or animal subject, and
- a drug dispenser comprising a drug repository containing at least one drug and a positive displacement element adapted to dispense the at least one drug from the housing into the region of the mucosal tissue disrupted by the electrically-actuatable portion.
Dependencies are inferred from the claim text.