Transdermal Systems for the Delivery of Therapeutic Agents Including Granisetron Using Iontophoresis

A method of providing transdermal delivery of a plurality of doses of a charged therapeutic substance comprising:

• (a) providing a skin-worn device comprising:
• (1) a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, said donor reservoir further including circuit elements that enable the delivery of a plurality of successive doses of a therapeutic substance;
• (2) a counter reservoir;
• (3) a source of electric power connected in a circuit between said donor reservoir and said counter reservoir;
• and
• (4) a control system for controlling current flow in said circuit to enable the plurality of successive doses of said therapeutic substance to be administered from said donor reservoir;
• (b) applying said skin-worn device to the skin of a patient;
• and
• (c) using said control system to control current flow in said circuit to provide a plurality of doses of said therapeutic substance.

A method of administering granisetron to the body of a patient comprising:

• (a) providing a disposable skin-worn patch device for the delivery of granisetron by iontophoresis, capable of providing a plurality of doses of granisetron to the body, comprising:
• (1) a donor reservoir containing granisetron, said donor reservoir further including a source of reactive material for providing a plurality of successive doses of a granisetron;
• (2) a counter reservoir;
• (3) a source of electrical power;
• and
• (4) a control system for controlling administration using a first completed circuit for supplying a primary dose of between about 300 μg and about 1000 μg of granisetron in a less than 2-hour time period upon application of the patch to the body surface, and user-operable device to allow user to self-administer sequentially an additional dose of between about 300 μg and about 1000 μg of granisetron;
• (b) applying said device to the skin of a patient;
• and
• (c) using said user operable device to administer an additional dose of granisetron when desired.

A disposable skin-worn device for the transdermal delivery of a plurality of doses of a charged therapeutic substance by iontophoresis comprising:

• (a) a donor reservoir containing an amount of a therapeutic substance to be delivered transdermally by iontophoresis, said donor reservoir further including elements for providing a plurality of successive doses of a therapeutic substance;
• (b) a counter reservoir;
• (c) a source of electric power connected in a circuit between said donor reservoir and said counter reservoir;
• and
• (d) a user-operable control system to enable the plurality of successive doses of said therapeutic substance to be administered from said donor reservoir.