Friedel-Crafts acylation for the synthesis of aryl- and heteroaryl-(3-ethyl-4-nitrophenyl)-methanones
OwnerBernhard Knippinventor
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Abstract
The present invention concerns a synthesis process comprising the following steps (i) reacting 3-ethyl-4-nitrobenzoic acid with thionyl chloride to produce a 3-ethyl-4-nitrobenzoic acid chloride or a 3-ethyl-4-nitrobenzoic acid anhydride from 3-ethyl-4-nitrobenzoic acid by means of water cleavage and (ii) Friedel-Crafts acylation by reacting the 3-ethyl-4-nitrobenzoic acid chloride or the 3-ethyl-4-nitrobenzoic acid anhydride with an optionally substituted aryl-H to form an optionally substituted (3-ethyl-4-nitrophenyl)-aryl-methanone. In addition the present invention concerns compounds containing (3-ethyl-4-nitrophenyl)-aryl-methanone, characterized in that the optionally substituted aryl is an optionally substituted condensed aromate.
Claims15
A synthesis process comprising the following steps
- a) reacting 3-ethyl-4-nitrobenzoic acid with a thionyl halide to produce a 3-ethyl-4-nitrobenzoic acid halide;
- and
- b) Friedel-Crafts acylation by reacting the 3-ethyl-4-nitrobenzoic acid chloride or the 3-ethyl-4-nitrobenzoic acid anhydride with an optionally substituted aryl-H to form an optionally substituted (3-ethyl-4-nitro-phenyl)-aryl-methanone.
A compound of the formula (3-Ethyl-4-nitrophenyl)-aryl-methanone or [3-(2-hydroxy-1-methyl-ethyl)-4-nitrophenyl]-aryl-methanone, wherein the optionally substituted aryl is a condensed aromate, which is optionally substituted.
Dependencies are inferred from the claim text.