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US 2011/0087010 A1Published application
Anti-angiogenic compounds
AssigneeCovx Technologies Ireland Limited
InventorsCurt W. BRADSHAW, Venkata Ramana DOPPALAPUDI, Jing-Yu LAI, John RIZZO
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Abstract
The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
Claims17
1-175. (canceled)
A compound of the formula:
- wherein Z is of the formula:
- wherein Antibody is an aldolase catalytic antibody, and v is 1, 2, 3, 4, or 5;
- w is 1, 2, 3, 4, or 5;
- and Rb is hydrogen, substituted or unsubstituted C1-10 alkyl, substituted or unsubstituted C3-7 cycloalkyl-C0-6 alkyl, or substituted or unsubstituted aryl-C0-6 alkyl, and q is 0, 1, 2 or 3.
1 more element
A compound of the formula:
- wherein Antibody is an aldolase catalytic antibody, and v is 1, 2, 3, 4, or 5;
- w is 1, 2, 3, 4, or 5;
- and Rb is hydrogen, substituted or unsubstituted C1-10 alkyl, substituted or unsubstituted C3-7 cycloalkyl-C0-6 alkyl, or substituted or unsubstituted aryl-C0-6 alkyl, q is 0, 1, 2 or 3, and AAn-AA2-AA1-N is an Anti-Angiogenic peptide.
A compound of the formula:
A compound of the formula:
A compound of the formula:
Dependencies are inferred from the claim text.