Enhanced oral transcompartmental delivery of therapeutic or diagnostic agents

A transcompartmental delivery promoting composition comprising:

• a) a polymer having multiple functional groups, at least one of which is covalently bound to a peptide independently selected from the group consisting of SEQ ID NOS:
• 1-8, and at least one cell uptake promoter covalently bound to said peptide selected from the group consisting of SEQ ID NOS:
• 1-8;
• or
• b) a polymer and at least one cell uptake promoter bound thereto;
• the polymer further comprising multiple functional groups at least one of which is covalently bound to at least one peptide selected independently from the group consisting of SEQ ID NOS:
• 1-8;
• wherein said polymer of (a) or (b) is selected from the group consisting of carboxymethylcellulose, dextran, polyvinyl alcohol, polyvinyl pyrrolidone, poly-1,3-dioxolane, poly-1,3,6-trioxane, an amino acid homopolymer, polypropylene oxide, a copolymer of ethylene glycol/propylene glycol, an ethylene/maleic anhydride copolymer, an amino acid copolymer, a copolymer of polyethylene glycol and an amino acid, a polypropylene oxide/ethylene oxide copolymer, and a polyethylene glycol/thiomalic acid copolymer;
• and any combination thereof,
• and wherein further each cell uptake promoter of (a) or (b) is independently selected from the group consisting of biotin, folate, pantothenate, B-6, B-12, glucose, N-acetyl glucosamine, RANTES, IL-2, Tat, penetratin, VEGF, RI TAT, gp41, VEGF, myristic acid, stearic acid, aptamers containing 5-(1-pentyl)-2′-deoxyuridine neuramimidase, CD4, CD44, influenza virus hemagglutinin, estrogen, progesterone, LHRH, ACTH, growth hormone, lectins, ICAM and analogues thereof.