Method and System to Detect, Diagnose, and Monitor the Progression of Alzheimer's Disease
OwnerDiego Mastroeni, Joseph Rogers +2inventors
InventorsDiego Mastroeni, Joseph Rogers, Andrew Grover, Paul D. Coleman
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Abstract
Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of Alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate labeling the sample to identify at least one epigenetic marker; determining an amount of the at least one epigenetic marker; comparing the amount to a reference value; and determining a state of Alzheimer's disease.
Claims24
A method for determining a state of Alzheimer's disease, the method comprising:
- placing a sample comprising at least one blood component onto a substrate;
- labeling the sample to identify at least one epigenetic marker;
- determining an amount of the at least one epigenetic marker;
- comparing the amount to a reference value;
- and
- determining a state of Alzheimer's disease.
A method for determining a state of Alzheimer's disease in a patient, the method comprising:
- receiving a blood sample from a patient;
- separating leukocytes from the blood sample;
- binding an antibody to at least one epigenetic marker in the leukocytes;
- attaching a label to the antibody;
- determining an amount of the label;
- and
- determining the state of Alzheimer's disease in the patient based on the amount of the label.
The method according to claim 16, further comprising determining the state of Alzheimer's disease based on the amount of the label and based on the amount of the second label.
A system for determining a state of Alzheimer's disease, the apparatus comprising:
- a substrate comprising a top surface and a bottom surface;
- at least one detail on the top surface of the substrate;
- at least one antibody operative to bind at least one epigenetic marker in a sample comprising leukocyte, the at least one antibody located in the at least one detail;
- and
- a reference value comprising a known amount of the at least one epigenetic marker.
Dependencies are inferred from the claim text.