Sensory-specific local anesthesia and prolonged duration local anesthesia
AssigneesMassachusetts Institute of Technology, Children's Medical Center Corporation
InventorsDaniel S. Kohane, Itay Sagie
Life of this patent
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Abstract
Combinations of charged local anesthetics with chemical permeation enhancers have been developed to give long duration block which is selective for sensory block over motor block. The duration of block is greatly prolonged by combining the local anesthetic with a permeation enhancer. The selectivity of sensory over motor block is provided by selecting the concentration of the local anesthetic and the permeation enhancer to provide selective permeability of the sensory and motor neurons to the enhancer.
Claims27
A method for selective sensory nerve blockade comprising administering a combination of a charged local anesthetic selected from the group consisting of amino-amide or amino-ester local anesthetics or derivatives thereof, at least partly amphiphilic local anesthetics, local anesthetics that act not on the outer surface of the cell, and at least partly charged local anesthetics, and a chemical permeation enhancer selected from the group consisting of surfactants, terpenes, amino amides, amino esters, azide-like compounds and alcohols, in a suitable pharmaceutically acceptable carrier.
A composition for selective sensory nerve blockade comprising a combination of a charged local anesthetic selected from the group consisting of amino-amide or amino-ester local anesthetics or derivatives thereof at least partly amphophilic local anesthetics, local anesthetics that act not on the outer surface of the cell, and at least partly charged local anesthetics, and a chemical permeation enhancer selected from the group consisting of surfactants, terpenes, amino amides, amino esters, azide-like compounds and alcohols, in a suitable pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.