Derivatives of Propane Diyl Dicinnamate
AssigneeToronto Institute of Pharmaceutical Technology
InventorALEXANDER MACGREGOR
Life of this patent
Estimating the term…
Abstract
The present invention provides a method for treating a cancer in a subject involving administering to the subject a compound of formula (II) or (II′): wherein R1, R2, R3, R4, R5, R6 and R7 are independently H, OH, alkylcarbonyloxy, or a pharmaceutically acceptable salt thereof. Also provided is a compound of formula (II) or (II)′, wherein R1 and R2 are independently OH, alkoxy or alkylcarbonyloxy, R3 and R4 are independently H, OH, alkoxy or alkylcarbonyloxy, R6 is H, alkoxy or alkylcarbonyloxy, R5 is H, OH or alkylcarbonyloxy, R6 is H or alkoxy, and R7 is H, or a pharmaceutically acceptable salt thereof.
Claims41
A compound of formula (I) or (I′):
- wherein:
- R1 and R2 are independently OH, alkoxy or alkylcarbonyloxy,
- R3 and R4 are independently H. OH, alkoxy or alkylcarbonyloxy, and
- R5 is H, OH or alkylcarbonyloxy, and
- R6 is H or alkoxy,
- or a pharmaceutically acceptable salt thereof,
- provided that the compound is not
- (E)-2-acetoxy-3-(((E)-3-(3,4-dimethoxyphenyl)acryloyl)oxy)propyl 3-(4-methoxyphenyl)acrylate, or
- (E)-3-(((E)-3-(3,4-dimethoxyphenyl)acryloyl)oxy)-2-hydroxypropyl 3-(4-methoxyphenyl)acrylate.
A method for treating a cancer in a subject, comprising administering to the subject a compound of formula (II) or (II′):
- wherein R1, R2, R3, R4, R5, R6 and R7 are independently H, OH, alkoxy or alkylcarbonyloxy, or
- a pharmaceutically acceptable salt thereof,
- provided that the compound is other than (2E,2′E)-2-acetoxypropane-1,3-diyl bis(3-(4-hydroxyphenyl)acrylate) and (E)-2-acetoxy-3-(((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)oxy)propyl 3-(4-hydroxyphenyl)acrylate.
A pharmaceutical composition comprising:
- wherein:
- R1 and R2 are independently OH, alkoxy or alkylcarbonyloxy,
- R3 and R4 are independently H, OH, alkoxy or alkylcarbonyloxy, and
- R5 is H. OH or alkylcarbonyloxy, and
- R6 is H or alkoxy,
- or a pharmaceutically acceptable salt thereof, and
- a pharmaceutically acceptable diluent or carrier,
- provided that the compound is not
- (E)-2-acetoxy-3-(((E)-3-(3,4-dimethoxyphenyl)acryloyl)oxy)propyl 3-(4-methoxyphenyl)acrylate, or
- (E)-3-(((E)-3-(3,4-dimethoxyphenyl)acryloyl)oxy)-2-hydroxypropyl 3-(4-methoxyphenyl)acrylate.
An intermediate of the formula:
- wherein R1 and R2 are both alkoxy.
41-88. (canceled)
Dependencies are inferred from the claim text.