Barium salt of benzimidazole derivative
OwnerYatendra KUMAR, Mahavir Singh Khanna +1inventors
InventorsYatendra KUMAR, Mahavir Singh Khanna, Mohan Prasad
Life of this patent
Estimating the term…
Abstract
The invention relates to crystalline barium salt of (S)-omeprazole, which is (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole. The invention also relates to processes for preparing crystalline barium salt of (S)-omeprazole and pharmaceutical compositions that include the crystalline barium salt of (S)-omeprazole so prepared.
Claims20
Crystalline barium salt of (S)-omeprazole prepared by using a process comprising the step of contacting (S)-omeprazole freebase, or its salt, with a barium containing compound that is capable of forming the barium salt (S)-omeprazole in a solvent, provided that a base is used when (S)-omeprazole base is used as the starting material, wherein the solvent comprises ketones, alcohols, esters, cyclic ethers, chlorinated hydrocarbons, nitriles, dipolar aprotic solvents, and mixtures thereof.
The crystalline barium salt of (S)-omeprazole according to 1, wherein the solvent has been removed from the crystalline barium salt of (S)-omeprazole.
A pharmaceutical composition comprising a crystalline barium salt of (S)-omeprazole and an additional therapeutic agent.
A pharmaceutical composition comprising a crystalline barium salt of (S)-omeprazole and an additional therapeutic agent, wherein the crystalline barium salt of (S)-omeprazole is prepared by using a process comprising the step of contacting (S)-omeprazole freebase, or its salt, with a barium containing compound that is capable of forming the barium salt (S)-omeprazole in a solvent, provided that a base is used when (S)-omeprazole base is used as the starting material, wherein the solvent comprises ketones, alcohols, esters, cyclic ethers, chlorinated hydrocarbons, nitriles, dipolar aprotic solvents, and mixtures thereof.
Dependencies are inferred from the claim text.