Methods for treating viral disorders
AssigneeTrustees of Boston University
InventorsSUSAN P. PERRINE, DOUGLAS V. FALLER
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Abstract
Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent for an additional period of about sixteen days for a total cycle of about 21 days.
Claims20
A method for treating a viral disorder in a subject, comprising providing said subject with at least one cycle of therapy, said cycle of therapy comprising:
- i) administering to the subject over a first period an inducing agent to induce expression of a viral gene product in a virus-infected cell of the subject and an anti-viral agent whose anti-viral activity is directed to the viral gene product expressed, wherein said first period of time is less than or equal to one-half of the length of the cycle, and further wherein said inducing agent and said anti-viral agent are administered in the same or separate compositions;
- and
- ii) administering said anti-viral agent to the subject for a second period, wherein said second period is the remainder of the cycle.
A method for treating an HIV-associated disorder in a subject, comprising providing said subject with at least one cycle of therapy, said cycle of therapy comprising:
- i) administering to the subject over a first period of time:
- a) an anti-viral agent, and
- b) an inducing agent in an amount sufficient to induce expression of a viral gene product selected from the group consisting of EBV-thymidine kinase and HIV reverse transcriptase;
- and
- ii) continuing the administration of the anti-viral agent to the subject for the remainder of the cycle.
Dependencies are inferred from the claim text.