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US 2011/0086858 A1Published application
Compounds for the Treatment of Hepatitis C
AssigneeBristol-Myers Squibb Company
InventorsTao Wang, Annapurna Pendri, Zhongxing Zhang, Weixu Zhai, Guo Li, Samuel Gerritz, Paul Michael Scola, Li-Qiang Sun, Qian Zhao, Eric Mull
Life of this patent
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Abstract
The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
Claims15
A compound of formula I
- where
- R1 is alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, halocycloalkyl, cycloalkenyl, benzyl, indanyl, or alkylcarbonyl;
- R2 is hydrogen, cyano, halo, alkyl, haloalkyl, alkoxy, or haloalkoxy;
- R3 is hydrogen, alkyl, (amino)alkyl, (alkylamino)alkyl, (dialkylamino)alkyl, ((alkylcarbonyl)amino)alkyl, ((haloalkylcarbonyl)amino)alkyl, ((alkoxycarbonyl)amino)alkyl, ((benzyloxycarbonyl)amino)alkyl, alkylcarbonyl, alkoxycarbonyl, benzyloxycarbonyl, aminocarbonyl, alkylaminocarbonyl, or dialkyaminocarbonyl;
- R4 is hydrogen, alkyl, (amino)alkyl, (alkylamino)alkyl, or (dialkylamino)alkyl;
- R5 is hydrogen, alkyl, (amino)alkyl, (alkylamino)alkyl, or (dialkylamino)alkyl;
- R6 is pyrollidinyl, piperidinyl, or piperazinyl and is substituted with 0-3 substituents selected from alkyl, alkylcarbonyl, alkoxycarbonyl, and benzyloxycarbonyl;
- Q is an alkylene or alkenylene chain containing 0-6 groups selected from the group consisting of O, NR3, S, S(O), S(O2), C(O)O, C(O)NR4, OC(O)NR4, NR4C(O)NR4, and Z, provided that any O or S atom does not directly bond to another O or S atom, such that ring A is 12-31 membered;
- and where the alkylene or alkenylene chain is substituted with 0-6 substituents selected from the group consisting of alkyl, hydroxy, alkoxy, R6, (R6)alkyl, and phenyl where the phenyl substituent is further substituted with 0-4 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy;
- X is O, CH2, CO, CO2, or C(O)NR5;
- and
- Z is C3-7 cycloalkylene, phenylene, pyrrolidindiyl, piperidindiyl, or piperazindiyl;
- or a pharmaceutically acceptable salt thereof.
10 more elements
Dependencies are inferred from the claim text.